BiOStyle Clinic OSAKA

REGENERATIVE
MEDICINE

Dermal fibroblast therapy

ABOUT

About Dermal Fibroblast Therapy

Regeneration at the cellular level.
Increasing youthful cells.

Dermal fibroblast therapy is regenerative medicine in which fibroblasts collected from your own skin are cultured and transplanted into the areas of skin that concern you.

As fibroblasts increase and collagen, elastin and hyaluronic acid are produced, an anti-aging effect on the skin can be expected.

It aims to address at its source the skin aging — wrinkles, sagging and the like — that results from the decline in skin cells (fibroblasts) with age.

Cross-section of the skin. Fibroblasts sit in the dermis beneath the epidermis, producing collagen and elastin fibers
Fibroblasts sit in the dermis and support the skin's firmness and elasticity.

Fibroblasts sit in the dermis and are important cells that produce collagen, hyaluronic acid and elastin, supporting firmness and elasticity.

They decline, however, with age and with exposure to ultraviolet light.

We collect and culture your own cells, expand them and transplant them into the skin, working toward the recovery of your skin's natural condition.

Using your own dermal fibroblasts, collected and cultured, we provide regenerative medicine made to order for the state of your skin.

While preserving the skin's natural health and beauty, we address the way the skin's environment changes with age.

MECHANISM

How It Works

01 ── Testing

Before the procedure you undergo testing for infectious diseases and the like. Blood for cell culture is drawn at the same time as the blood test.

02 ── Collection

A piece of skin measuring 7 mm by 3 mm — about the size of a grain of rice — is taken from an inconspicuous spot behind the ear. Almost no scar remains.

Taking a piece of skin about the size of a grain of rice from behind the ear
Collecting the skin sample
The collection site behind the ear, about 7 mm by 3 mm and in an inconspicuous position
Collection site (behind the ear)

03 ── Culture

Fibroblasts are cultured from the skin collected. The culture period is four weeks.

Transferring the collected skin into a container of preservation solution
The collected skin is transferred to a storage container.

04 ── Transplantation

The cultured cells are transplanted into the areas of skin that concern you.

Transplanting the cultured fibroblasts into the skin
The cultured cells are transplanted into the areas that concern you.

EFFECT

Main Effects

Under-eye shadows

By promoting collagen production and reinforcing thinned skin from within, it makes under-eye shadows less noticeable.

Nasolabial folds

By supporting volume from within, it makes nasolabial folds less noticeable for a natural, more youthful look.

Wrinkles

By raising the skin's internal regenerative capacity and restoring collagen structure, it aims to improve wrinkles from fine lines to deep folds.

Sagging

By promoting the production of the components behind elasticity, a tightening and lifting effect along the jawline can be expected.

What we aim for

Slowing the pace of aging.

Maintaining skin quality and skin firmness.

FAQ

Frequently Asked Questions

PatientPatient

What kind of treatment is dermal fibroblast therapy?

PhysicianPhysician

It is regenerative medicine in which fibroblasts collected from your own skin are cultured, expanded and transplanted into the skin.

By replenishing the very cells that produce collagen, elastin and hyaluronic acid, it addresses skin aging at its source.

PatientPatient

How long before I see an effect?

PhysicianPhysician

It takes time for the transplanted fibroblasts to settle in and begin producing collagen and other components.

Generally the change is felt gradually over one to three months after the procedure, with the effect tending to stabilize at around six months.

PatientPatient

How long does the effect last?

PhysicianPhysician

Because the transplanted cells settle in as part of your own tissue, the effect can be expected to last longer than with hyaluronic acid injections.

How long it lasts varies from person to person, but it is expected to hold for a matter of years.

PatientPatient

Is there pain or downtime?

PhysicianPhysician

Anesthesia is used when the skin is collected and transplanted, so pain during the procedure is limited.

Temporary redness or swelling can appear at the transplant site, but in most cases it settles within a few days.

PatientPatient

Is there any risk of allergy or rejection?

PhysicianPhysician

Because your own cells are cultured and used, the risk of allergy or rejection is extremely low.

It is carried out under a safety management framework for which notification has been filed as Class II regenerative medicine.

PatientPatient

Which areas can be treated?

PhysicianPhysician

It suits areas that move a great deal with expression, such as under-eye shadows, nasolabial folds, and fine lines on the forehead and around the mouth.

Please raise any areas that concern you at your consultation.